Bioanalytical Analyst

Company: Axelon Services Corporation
Location: Chesterfield
Posted on: March 19, 2023

Job Description:

Bioanalytical Analyst
Chesterfield, MO
3 Years

Onsite 4-5 days

Job Description: POSITION SUMMARY:
As part of the Analytical Research and Development (ARD) group in Biotherapeutics Pharmaceutical Sciences, we are seeking an enthusiastic, self-driven, and optimistic a B.S., M.S., or Ph.D. degree (with at least 7+, 5+, and 0-3 years of work experience, respectively) level candidate specializing in the mass spectrometry (MS). The successful candidate will provide support for LC-MS and LC-MS/MS method development and qualification in support of quantitation of mRNA expressed proteins in cells as well as in-depth structural elucidation of these proteins. As such, candidate should have in-depth understanding and hands-on experience with the characterization of antibodies, proteins, and/or vaccine products that includes commensurate technical knowledge and skills. Candidates should be comfortable working at the interface of analytical chemistry, biochemistry, cell biology, as well as interacting with cross-site research groups. Excellent written and communication skills, effective time-management, an innovative spirit, and the ability and desire to work both independently and collaboratively in a multidisciplinary, fast-paced, team-oriented environment are essential for the position.

POSITION RESPONSIBILITIES:
" Develop, qualify, and benchmark the LC-MS and/or LC-MS/MS quantitative method to monitor expression of proteins in cells post mRNA transfection.
" Develop Client strategies and methods with the latest UHPLC and MS technologies for more informative and efficient product characterization and process monitoring.

EDUCATION AND EXPERIENCE:
" Candidates should have a B.S., M.S., or Ph.D. degree (with at least 7+, 5+, and 2-3 years of work experience, respectively) in chemistry, biochemistry or related field, and a primary focus on protein mass spectrometry, commensurate with graduate studies, postdoctoral research, and/or work experience.

TECHNICAL SKILLS REQUIREMENTS:
" Specialization in protein mass spectrometry (LC/MS, LC/MS/MS) is required. Experience with state-of-the-art MS and proficiency in data analysis is expected.
" Extensive hands-on experience with qualitative and quantitative protein analysis is required.
" Extensive experience with well-established MS approaches and methods for the detailed structural analysis of therapeutic proteins is required.
" Familiarity with mRNA/DNA and protein therapeutics is highly desired with respect to structural characterization approaches, challenges and gaps, and regulatory principles.
" MS-based method development experience is highly desired for implementing more informative and efficient approaches to product characterization and process monitoring

PHYSICAL POSITION REQUIREMENTS:
" Position requires typical physical conditions for standard laboratory and office work
" Ability to perform mathematical calculations and ability to perform complex data analysis.

Required Skills:
1. Ph.D. preferred,
2. Advanced technology - Mass Spectrometry (Data Processing)
3. Hit the ground Running
4. mRNA Project, protein expression

Preferred Skills:
1. Self-Starter
2. Independent
3. Fast learner
4. Team Player (Collaborate with multiple teams)
5. Cell Culture Experience
6. Protein Purification, immunoprecipitation

Keywords: Axelon Services Corporation, Chesterfield , Bioanalytical Analyst, Professions , Chesterfield, Missouri